Focus - Using pharmacometric approaches to build exposure response relationship for a new anti-malarial drug

• Developed a population logistic and time to event regression models in NONMEM for understanding relationship between tafenoquine exposure and malaria relapse rates using data from 3 pivotal studies
• Developed population pharmacokinetic model for an in-development drug using circadian rhythm patterns for drug-receptor binding dynamics

Focus - Using pharmacometric approaches to understand pharmacokinetics of antiepileptics in special populations

• Using population NLME models for characetrizing pregnancy and postpartum related PK-PD changes of lamotrigine
• Developing breastfeeding PBPK models for predicting lamotrigine exposure in infants from breastfeeding
• Using stochastic simulation and estimating methods to identify dosing algorithms for lamotrigine in pregnancy and postpartum

Focus - Using pharmacometric approaches to optimize and individualize therapy in oncology

• Used Population PK approaches to establish bioequivalence of a rituximab biosimilar
• Developed a pharmacometric model of paclitaxel to analyze effect of BMI on exposure
• Used D-optminal sampling to develop and initiate a study to characterize colistin PK in bone marrow transplant patients

Focus - Development and validation of bioanalytical methods on chromatographic/mass spectroscopic systems

• Method development and validation of protein-based drugs especially insulin analogues
• Developing and maintaining method standard operating procedures